Research progress on the role of lncRNA–miRNA networks in regulating adipogenic and osteogenic differentiation of bone marrow mesenchymal stem cells in osteoporosis

Osteoporosis (OP) is characterized by a decrease in osteoblasts and an increase adipocytes the bone marrow compartment, alongside abnormal bone/fat differentiation, which ultimately results imbalanced homeostasis. Bone mesenchymal stem cells (BMSCs) can differentiate into to maintain Several studies have shown that lncRNAs are competitive endogenous RNAs form lncRNA–miRNA network targeting miRNA for regulation of differentiation BMSCs; this mechanism closely related corresponding treatment OP important development novel OP-targeted therapies. However, reviewing current literature, it became clear there limited summaries discussing effects on osteogenic/adipogenic BMSCs. Therefore, article provides review literature explore impact BMSCs, with aim providing new theoretical basis OP.